Twenty-five NHS trusts in England should be investigated over higher than normal death rates, a leading health expert has warned the government.
Prof Brian Jarman said a total of 4,600 more patients had died at those trusts in 2007-08 than would be expected.
He told the BBC
a higher than expected death rate did not necessarily prove hospitals were doing anything wrong, but could help identify wider problems.
The government said trusts with high death rates had already been checked.
Mortality alerts
Prof Jarman, who is an emeritus professor at London's Imperial College School of Medicine, told the BBC
he had identified a number of NHS trusts in England with a higher than expected Hospital Standardised Mortality Ratio (HSMR).
He argues that, when combined with other factors, a high HSMR can indicate broader problems with patient care.
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THE 25 TRUSTS
Barking, Havering and Redbridge University Hospitals NHS Trust
Basildon and Thurrock University Hospitals NHS Foundation Trust
Blackpool, Fylde and Wyre Hospitals NHS Foundation Trust
Central Manchester University Hospitals NHS Foundation Trust
Colchester Hospital University NHS Foundation Trust
George Eliot Hospital NHS Trust
Great Western Hospitals NHS Foundation Trust
Heart Of England NHS Foundation Trust
Hull and East Yorkshire Hospitals NHS Trust
James Paget University Hospitals NHS Foundation Trust
Mayday Healthcare NHS Trust
Mid Cheshire Hospitals NHS Foundation Trust
Mid Staffordshire NHS Foundation Trust
Mid Yorkshire Hospitals NHS Trust
North Middlesex University Hospital NHS Trust
Pennine Acute Hospitals NHS Trust
Royal Bolton Hospital NHS Foundation Trust
Sherwood Forest Hospitals NHS Foundation Trust
Southampton University Hospitals NHS Trust
Stockport NHS Foundation Trust
Tameside Hospital NHS Foundation Trust
United Lincolnshire Hospitals NHS Trust
University Hospital Birmingham NHS Foundation Trust
University Hospitals Coventry and Warwickshire NHS Trust
Wrightington, Wigan and Leigh NHS Foundation Trust
Source: Prof Brian Jarman
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"There are 25 hospitals which have an HSMR which is extremely high, and [where] we have found four or more mortality alerts," he said.
A mortality alert is triggered by higher than expected deaths for a particular procedure.
Prof Jarman said each of the trusts in question had at least 150 more deaths than expected in the year 2007-08.
Across the 25 trusts, there were 4,600 unexpected deaths in total.
He acknowledged there may have been some problems with the way the deaths were recorded, but called on the government to ask the Care Quality Commission (CQC) to investigate each of the trusts rather than relying on their own self-assessments.
"These are ones which I would think it would be worth investigating.
"I have sent the data to the Secretary of State Andy Burnham. I haven't had a response."
The self-assessment system has been widely discredited, and Prof Jarman, a former British Medical Association president, is a long-standing critic of it.
Earlier this month, the BBC
's Panorama programme highlighted the discrepancy between many hospitals' own assessments of their performances and the conclusions of inspectors who carried out investigations.
Prof Jarman said: "The regulator uses a method which I think is fundamentally flawed, which is that only 20% of hospitals are inspected every year.
"They are assessing 20% of the cases in the hospital. So that's 20% of 20% which is 4%.
"But when you look at that 4% and see whether the self-assessment agrees with the actual on-site inspection for the hospitals that are at risk, two-thirds of the self-reporting is in fact incorrect."
In response, health minister Mike O'Brien said: "We'll look at Professor Jarman's letter, but the CQC has conducted a regional review of all the trusts identified as having high mortality ratios.
"It confirmed in January that - at that time - they had no current concerns that they would be as bad as Mid Staffordshire clearly was."
Last month an independent inquiry into the Mid Staffordshire NHS Trust detailed evidence of systematic failings which caused "unimaginable" patient distress and suffering, despite being rated as a "fair" hospital by the NHS for most of the period in question.
Last year it had been reported there were at least 400 more deaths than expected at the trust from 2005 to 2008.
Unannounced visits
Mr O'Brien acknowledged that the self-assessment system does have limitations.
"Self-assessment I think has in the past been over-relied upon and that's why we've changed the way in which regulation is carried out.
"In the new system of registration, every hospital gets visited every two years, but if there's a higher risk then it'll be more often than that - and [the CQC] can make unannounced visits at any time," he said.
"What they do not do is leave unchallenged the views of hospitals about the way in which they are behaving."
And the minister warned that, under the new rules, a hospital which failed to meet adequate standards could face having its registration made conditional or even removed altogether, meaning it would no longer be able to operate.


A grandmother took her own life days after a psychiatric medical team at a hospital decided not to admit her as she was at a "low risk" of self harm.
An inquest heard Avril Thorne, 49, of the Sandfields area of Port Talbot, hanged herself in March 2006.
Recording a narrative verdict, Neath Port Talbot coroner Philip Rogers said he was "absolutely satisfied" the system did not work at the time.
The inquest heard emergency outpatient clinic appointments had since changed.
Mr Rogers was told that Mrs Thorne had a history of psychiatric illness, which started a number of years before her death, when she discovered that her daughter was using Class A drugs.
As a result, Mrs Thorne and her husband Paul started looking after their granddaughter, and the inquest was told that she found it stressful and difficult.
On 25 March, Mr Thorne called the out-of-hours GP service, because Mrs Thorne told him she needed help.
A doctor visited their home and assessed her to be "suicidal" and referred her to hospital.
She went to Ward F of Neath Port Talbot Hospital - a specialist psychiatric ward for adult patients.
But an assessment by staff nurse Lindsay Martin and the senior doctor on call on the ward Mahibur Rahman found she was at "low to some" risk of self harm.
Dr Rahman discharged her with a three point action plan and referred Mrs Thorne to the out-of-hours psychiatric service, to be monitored over the weekend.
He also referred her to a day hospital, for extra support, and to her consultant psychiatrist for a possible change of medication.
Mrs Thorne had been taking the anti-depressant, Amitriptyline for several months.
But the coroner said the evidence proved "no effective steps" were taken to deal with her case after the 25 March.
Mrs Thorne was found dead at her home five days later.
Mr Rogers said: "I cannot say whether it was a system operating wrongly, or not adequately at the time, but I do accept the system has fundamentally changed since."
In a statement the Abertawe Bro Morgannwg University Health Board said it again wished to apologise and extend condolences to Mrs Thorne's family.
"Devastating loss"
It said following her death a specialist treatment service was set up which was now responsible for the assessment, provision of emergency follow up treatment and liaison with community services.
"Other actions have also been taken to improve our service, including better communication systems between senior clinical staff and the teams looking after patients," it added.
In a statement through his solicitors Mr Thorne said: "Our whole family have been devastated by the loss of Avril.
"I sincerely hope that the NHS does not let this happen to any other family.
"Had Avril received the support she needed then her tragic death would have been avoided.
"Avril was a lovely popular person who is very much missed by all who knew her."
http://news.bbc.co.uk/1/hi/wales/south_west/8586110.stm